Compound Detail
CHEMBL89697
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Basic Information
| ChEMBL ID | CHEMBL89697 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DWJWWZSAYOTJGO-XYOKQWHBSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
8
Publications
0
Known Names
Molecular Properties
225.2
MW (Da)
3.08
ALogP
2
HBA
1
HBD
42.2
PSA (Ų)
0.76
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.13
Ki 1 meas. best 5.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A CHEMBL2292 | Ki | 5.36 | 5.36 | 4400.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL3337 | IC50 | 4.13 | 4.13 | 74131.0 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL3516 | IC50 | 4.13 | 4.13 | 73600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Ki | = | 4400.0 | nM | 5.36 | Binding affinity to DYRK1A (unknown origin) assessed as inhibition constant by A... | 34143631 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 74131.02 | nM | 4.13 | Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1) | 10956210 |
| Vascular endothelial growth factor receptor 1 | IC50 | = | 73600.0 | nM | 4.13 | Concentration required to achieve 50% inhibition of tyrosine phosphorylation on ... | 9651163 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10956210 | 10.1021/jm990609e | Vascular endothelial growth factor receptor 2 | 1 |
| 9651163 | 10.1021/jm980123i | Platelet-derived growth factor receptor beta | 1 |
| 9651163 | 10.1021/jm980123i | Vascular endothelial growth factor receptor 1 | 1 |
| 9651163 | 10.1021/jm980123i | Epidermal growth factor receptor | 1 |
| 9651163 | 10.1021/jm980123i | Receptor tyrosine-protein kinase erbB-2 | 1 |
| 9651163 | 10.1021/jm980123i | Insulin-like growth factor 1 receptor | 1 |
| 34143631 | 10.1021/acs.jmedchem.1c00024 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
| 34143631 | 10.1021/acs.jmedchem.1c00024 | Serine/threonine-protein kinase PAK 4 | 1 |
Data from ChEMBL 36 via Core Engine