Assay Detail
Binding
CHEMBL818398
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 1 (CHEMBL3516) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 5.50 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL86943 | — | — | 1 | 7.16 |
| CHEMBL313433 | — | — | 1 | 6.85 |
| CHEMBL316008 | — | — | 1 | 6.75 |
| CHEMBL89483 | — | — | 1 | 6.52 |
| CHEMBL86755 | — | — | 1 | 6.41 |
| CHEMBL89363 | — | — | 1 | 6.40 |
| CHEMBL328710 | — | — | 1 | 6.10 |
| CHEMBL330321 | — | — | 1 | 6.00 |
| CHEMBL276711 | SEMAXANIB | 3.0 | 1 | 5.98 |
| CHEMBL315546 | — | — | 1 | 5.80 |
| CHEMBL90277 | — | — | 1 | 5.68 |
| CHEMBL89721 | — | — | 1 | 5.63 |
| CHEMBL89040 | — | — | 1 | 5.60 |
| CHEMBL86480 | — | — | 1 | 5.60 |
| CHEMBL313578 | — | — | 1 | 5.57 |
| CHEMBL316020 | — | — | 1 | 5.57 |
| CHEMBL314217 | — | — | 1 | 5.52 |
| CHEMBL89809 | — | — | 1 | 5.52 |
| CHEMBL431025 | — | — | 1 | 5.52 |
| CHEMBL314146 | — | — | 1 | 5.47 |
| CHEMBL421548 | — | — | 1 | 5.39 |
| CHEMBL89723 | — | — | 1 | 5.37 |
| CHEMBL315701 | — | — | 1 | 5.35 |
| CHEMBL329367 | — | — | 1 | 5.34 |
| CHEMBL48760 | — | — | 1 | 5.28 |
| CHEMBL316009 | — | — | 1 | 5.20 |
| CHEMBL87402 | — | — | 1 | 5.13 |
| CHEMBL87810 | — | — | 1 | 5.12 |
| CHEMBL89505 | — | — | 1 | 5.08 |
| CHEMBL85021 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL86943 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL313433 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL316008 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL89483 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL86755 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL89363 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL328710 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL330321 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL276711 | SEMAXANIB | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL315546 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL90277 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL89721 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL89040 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL86480 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL316020 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL313578 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL314217 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL89809 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL431025 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL314146 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL421548 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL89723 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL315701 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL329367 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL48760 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL316009 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL87402 | — | IC50 | = | 7410.0 | nM | 5.13 |
| CHEMBL87810 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL89505 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL85021 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL87783 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL86631 | — | IC50 | = | 20400.0 | nM | 4.69 |
| CHEMBL86921 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL85403 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL328452 | — | IC50 | = | 41200.0 | nM | 4.38 |
| CHEMBL87746 | — | IC50 | = | 46600.0 | nM | 4.33 |
| CHEMBL89697 | — | IC50 | = | 73600.0 | nM | 4.13 |
| CHEMBL86432 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL87325 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL89646 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL312826 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL420411 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL86837 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL87208 | — | IC50 | < | 780.0 | nM | - |
| CHEMBL313259 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL86945 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL87080 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL87324 | — | IC50 | < | 780.0 | nM | - |
| CHEMBL86944 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL314021 | — | IC50 | > | 100000.0 | nM | - |