Compound Detail
CHEMBL87325
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Basic Information
| ChEMBL ID | CHEMBL87325 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UUKMQWDTHJLSMU-WDZFZDKYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
255.2
MW (Da)
2.42
ALogP
3
HBA
2
HBD
88.0
PSA (Ų)
0.49
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 CHEMBL2148 | IC50 | 6.15 | 6.15 | 710.0 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL1913 | IC50 | 4.38 | 4.38 | 41700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 | IC50 | = | 710.0 | nM | 6.15 | Inhibitory activity against Janus Kinase 3 protein tyrosine kinase. | 12941344 |
| Platelet-derived growth factor receptor beta | IC50 | = | 41700.0 | nM | 4.38 | Test concentration required to achieve 50% inhibition of tyrosine phosphorylatio... | 9651163 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10956210 | 10.1021/jm990609e | Vascular endothelial growth factor receptor 2 | 1 |
| 12941344 | 10.1016/s0960-894x(03)00657-7 | Tyrosine-protein kinase JAK3 | 1 |
| 9651163 | 10.1021/jm980123i | Platelet-derived growth factor receptor beta | 1 |
| 9651163 | 10.1021/jm980123i | Vascular endothelial growth factor receptor 1 | 1 |
| 9651163 | 10.1021/jm980123i | Epidermal growth factor receptor | 1 |
| 9651163 | 10.1021/jm980123i | Receptor tyrosine-protein kinase erbB-2 | 1 |
| 9651163 | 10.1021/jm980123i | Insulin-like growth factor 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine