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Assay Detail

CHEMBL704113

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Binding
Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Tyrosine-protein kinase JAK3 (CHEMBL2148)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Mapping the kinase domain of Janus Kinase 3.
Adams C, Aldous DJ, Amendola S, Bamborough P, Bright C, Crowe S, Eastwood P, Fenton G, Foster M, Harrison TK, King S, Lai J, Lawrence C, Letallec JP, McCarthy C, Moorcroft N, Page K, Rao S, Redford J, Sadiq S, Smith K, Souness JE, Thurairatnam S, Vine M, Wyman B.
Bioorg Med Chem Lett (2003) 13 : 3105 -3110
PubMed 12941344 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 6.47 7.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL104963 1 7.58
CHEMBL323994 1 7.57
CHEMBL106571 1 7.52
CHEMBL106944 1 6.78
CHEMBL107166 1 6.72
CHEMBL105255 1 6.70
CHEMBL421213 1 6.68
CHEMBL107225 1 6.67
CHEMBL318390 1 6.63
CHEMBL106961 1 6.58
CHEMBL320646 1 6.46
CHEMBL104062 1 6.16
CHEMBL87325 1 6.15
CHEMBL104409 1 6.06
CHEMBL86755 1 6.05
CHEMBL321855 1 5.64
CHEMBL107273 1 5.31
CHEMBL104640 1 5.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL104963 IC50 = 26.0 nM 7.58
CHEMBL323994 IC50 = 27.0 nM 7.57
CHEMBL106571 IC50 = 30.0 nM 7.52
CHEMBL106944 IC50 = 168.0 nM 6.78
CHEMBL107166 IC50 = 190.0 nM 6.72
CHEMBL105255 IC50 = 200.0 nM 6.70
CHEMBL421213 IC50 = 210.0 nM 6.68
CHEMBL107225 IC50 = 213.0 nM 6.67
CHEMBL318390 IC50 = 235.0 nM 6.63
CHEMBL106961 IC50 = 260.0 nM 6.58
CHEMBL320646 IC50 = 350.0 nM 6.46
CHEMBL104062 IC50 = 700.0 nM 6.16
CHEMBL87325 IC50 = 710.0 nM 6.15
CHEMBL104409 IC50 = 870.0 nM 6.06
CHEMBL86755 IC50 = 900.0 nM 6.05
CHEMBL321855 IC50 = 2300.0 nM 5.64
CHEMBL107273 IC50 = 4900.0 nM 5.31
CHEMBL104640 IC50 = 7100.0 nM 5.15