Compound Detail
CHEMBL315701
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Basic Information
| ChEMBL ID | CHEMBL315701 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YKIYMEVKKILHAK-JXAWBTAJSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
304.4
MW (Da)
4.17
ALogP
2
HBA
1
HBD
32.3
PSA (Ų)
0.84
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 1 CHEMBL3516 | IC50 | 5.35 | 5.35 | 4500.0 | 1 |
| Receptor tyrosine-protein kinase erbB-2 CHEMBL1824 | IC50 | 4.03 | 4.03 | 92600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 1 | IC50 | = | 4500.0 | nM | 5.35 | Concentration required to achieve 50% inhibition of tyrosine phosphorylation on ... | 9651163 |
| Receptor tyrosine-protein kinase erbB-2 | IC50 | = | 92600.0 | nM | 4.03 | Concentration required to achieve 50% inhibition of tyrosine phosphorylation on ... | 9651163 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9651163 | 10.1021/jm980123i | Platelet-derived growth factor receptor beta | 1 |
| 9651163 | 10.1021/jm980123i | Vascular endothelial growth factor receptor 1 | 1 |
| 9651163 | 10.1021/jm980123i | Epidermal growth factor receptor | 1 |
| 9651163 | 10.1021/jm980123i | Receptor tyrosine-protein kinase erbB-2 | 1 |
| 9651163 | 10.1021/jm980123i | Insulin-like growth factor 1 receptor | 1 |
Data from ChEMBL 36 via Core Engine