Compound Detail
CHEMBL345943
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Basic Information
| ChEMBL ID | CHEMBL345943 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GKGQZMWDXTVJQI-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
410.8
MW (Da)
5.15
ALogP
6
HBA
1
HBD
69.2
PSA (Ų)
0.47
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 7.22 | 7.22 | 60.0 | 1 |
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 2 | IC50 | = | 60.0 | nM | 7.22 | Vascular endothelial growth factor receptor 2 inhibitory activity at 2 uM of ATP... | 10639280 |
| Vascular endothelial growth factor receptor 1 | IC50 | = | 1200.0 | nM | 5.92 | In vitro vascular endothelial growth factor receptor 1 inhibitory activity at 2 ... | 10639280 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor 1 | 1 |
| 10639280 | 10.1021/jm990345w | Vascular endothelial growth factor receptor 2 | 1 |
| 10639280 | 10.1021/jm990345w | Fibroblast growth factor receptor 1 | 1 |
| 10639280 | 10.1021/jm990345w | Unchecked | 1 |
| 10639280 | 10.1021/jm990345w | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine