Compound Detail

CHEMBL150632

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COC(=O)C1=C(C)N=C(C)/C(=C(/O)OC)C1c1cccc(OCc2nonc2C#N)c1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL150632
Phase	Preclinical
Structure Type	MOL
InChI Key	QDCGMJSGRZCKOA-LVZFUZTISA-N

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

424.4

MW (Da)

2.94

ALogP

HBA

HBD

140.1

PSA (Å²)

0.55

QED

Ro5 Violations

Rot. Bonds

First in Class Prodrug

EC50 1 meas. best 6.51

IC50 1 meas. best 6.23

Ki 1 meas. best 6.57

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Voltage-dependent L-type calcium channel subunit alpha-1D CHEMBL4132	Ki	6.57	6.57	270.0	1
Rattus norvegicus CHEMBL376	EC50	6.51	6.51	310.0	1
Voltage-dependent L-type calcium channel subunit alpha-1D CHEMBL4132	IC50	6.23	6.23	590.0	1

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Voltage-dependent L-type calcium channel subunit alpha-1D	Ki	=	270.0	nM	6.57	Binding affinity for L-type [Ca2+] channels was measured through displacement of...	9876109
Rattus norvegicus	EC50	=	310.0	nM	6.51	Vasodilator activity was measured on rat aorta in the presence of guanylate cycl...	9876109
Voltage-dependent L-type calcium channel subunit alpha-1D	IC50	=	590.0	nM	6.23	Inhibitory concentration for L-type [Ca2+] channels was measured through displac...	9876109

PubMed	DOI	Target Context	# Activities
9876109	10.1021/jm9803267	Rattus norvegicus	2
9876109	10.1021/jm9803267	Voltage-dependent L-type calcium channel subunit alpha-1D	2

Data from ChEMBL 36 via Core Engine