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Compound Detail

CHEMBL151533

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Cc1ccc(N2CCN(Cc3ccc4c(c3)OCC(=O)N4)CC2)cc1C

Basic Information

ChEMBL ID CHEMBL151533
Phase Preclinical
Structure Type MOL
InChI Key VYJSEMNZGPEKAE-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

351.4
MW (Da)
2.96
ALogP
4
HBA
1
HBD
44.8
PSA (Ų)
0.92
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H25N3O2
MW 351.45
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -1.58

Activity Summary

Ki 3 meas. best 8.16

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(4) dopamine receptor
CHEMBL219
Ki 8.16 8.16 6.9 1
D(3) dopamine receptor
CHEMBL234
Ki 7.11 7.11 78.5 1
D(2) dopamine receptor
CHEMBL217
Ki 6.46 6.46 346.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10602703 10.1021/jm990277d D(4) dopamine receptor 1
10602703 10.1021/jm990277d D(3) dopamine receptor 1
10602703 10.1021/jm990277d D(2) dopamine receptor 1

Data from ChEMBL 36 via Core Engine