Assay Detail
Binding
CHEMBL674990
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Binding affinity at Dopamine receptor D3 in CHO cells by radioligand displacement.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 6.41 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL149233 | — | — | 1 | 7.98 |
| CHEMBL151533 | — | — | 1 | 7.11 |
| CHEMBL150173 | — | — | 1 | 6.68 |
| CHEMBL151286 | — | — | 1 | 6.63 |
| CHEMBL149497 | — | — | 1 | 6.37 |
| CHEMBL346389 | — | — | 1 | 6.17 |
| CHEMBL147130 | — | — | 1 | 6.08 |
| CHEMBL147059 | — | — | 1 | 6.07 |
| CHEMBL150181 | — | — | 1 | 6.06 |
| CHEMBL150129 | — | — | 1 | 5.75 |
| CHEMBL345552 | — | — | 1 | 5.60 |
| CHEMBL346398 | — | — | 1 | - |
| CHEMBL348435 | — | — | 1 | - |
| CHEMBL147011 | — | — | 1 | - |
| CHEMBL146757 | — | — | 1 | - |
| CHEMBL267014 | L-745870 | — | 1 | - |
| CHEMBL149596 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL149233 | — | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL151533 | — | Ki | = | 78.5 | nM | 7.11 |
| CHEMBL150173 | — | Ki | = | 208.0 | nM | 6.68 |
| CHEMBL151286 | — | Ki | = | 232.0 | nM | 6.63 |
| CHEMBL149497 | — | Ki | = | 428.0 | nM | 6.37 |
| CHEMBL346389 | — | Ki | = | 679.0 | nM | 6.17 |
| CHEMBL147130 | — | Ki | = | 839.0 | nM | 6.08 |
| CHEMBL147059 | — | Ki | = | 859.0 | nM | 6.07 |
| CHEMBL150181 | — | Ki | = | 864.0 | nM | 6.06 |
| CHEMBL150129 | — | Ki | = | 1790.0 | nM | 5.75 |
| CHEMBL345552 | — | Ki | = | 2490.0 | nM | 5.60 |
| CHEMBL346398 | — | Ki | > | 3030.0 | nM | - |
| CHEMBL348435 | — | Ki | > | 3030.0 | nM | - |
| CHEMBL147011 | — | Ki | > | 3030.0 | nM | - |
| CHEMBL146757 | — | Ki | > | 3030.0 | nM | - |
| CHEMBL267014 | L-745870 | Ki | > | 3030.0 | nM | - |
| CHEMBL149596 | — | Ki | > | 3030.0 | nM | - |