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Compound Detail

CHEMBL1533107

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Cc1nn(-c2nc3ccccc3s2)c(N)c1-c1ccccc1

Basic Information

ChEMBL ID CHEMBL1533107
Phase Preclinical
Structure Type MOL
InChI Key GSMUXMUMERCXHJ-UHFFFAOYSA-N
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

306.4
MW (Da)
4.04
ALogP
5
HBA
1
HBD
56.7
PSA (Ų)
0.61
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H14N4S
MW 306.39
Aromatic Rings 4
Heavy Atoms 22
NP-Likeness -1.89

Activity Summary

EC50 4 meas. best 6.56

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 6.56 6.2667 277.0 3
Nuclear factor NF-kappa-B complex
CHEMBL2094258
EC50 5.01 5.01 9753.0 1

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine