Compound Detail
CHEMBL153425
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Basic Information
| ChEMBL ID | CHEMBL153425 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SMIXUQPTRQSJSE-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
278.3
MW (Da)
2.81
ALogP
5
HBA
1
HBD
67.7
PSA (Ų)
0.54
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 6.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Macrophage migration inhibitory factor CHEMBL2085 | Ki | 6.3 | 6.3 | 500.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Macrophage migration inhibitory factor | Ki | = | 500.0 | nM | 6.3 | Inhibitory activity against tautomerase macrophage migration inhibitory factor (... | 11170644 |
| Macrophage migration inhibitory factor | Ki | = | 500.0 | nM | 6.3 | Inhibition of human recombinant MIF tautomerase | 19090668 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11170644 | 10.1021/jm000386o | Macrophage migration inhibitory factor | 1 |
| 19090668 | 10.1021/jm801100v | Macrophage migration inhibitory factor | 1 |
Data from ChEMBL 36 via Core Engine