Assay Detail
Binding
CHEMBL711481
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Inhibitory activity against tautomerase macrophage migration inhibitory factor (MIF)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Macrophage migration inhibitory factor (CHEMBL2085) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Coumarin and chromen-4-one analogues as tautomerase inhibitors of macrophage migration inhibitory factor: discovery and X-ray crystallography.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.85 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13486 | — | — | 1 | 7.42 |
| CHEMBL153074 | — | — | 1 | 6.55 |
| CHEMBL153505 | — | — | 1 | 6.33 |
| CHEMBL153425 | — | — | 1 | 6.30 |
| CHEMBL358644 | — | — | 1 | 6.26 |
| CHEMBL150485 | — | — | 1 | 5.82 |
| CHEMBL150254 | — | — | 1 | 5.80 |
| CHEMBL358206 | — | — | 1 | 5.68 |
| CHEMBL1161326 | — | — | 1 | 5.58 |
| CHEMBL150302 | — | — | 1 | 5.54 |
| CHEMBL358640 | — | — | 1 | 5.51 |
| CHEMBL153064 | — | — | 1 | 5.37 |
| CHEMBL153406 | — | — | 1 | 5.24 |
| CHEMBL153002 | — | — | 1 | 5.21 |
| CHEMBL155103 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13486 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL153074 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL153505 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL153425 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL358644 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL150485 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL150254 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL358206 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL1161326 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL150302 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL358640 | — | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL153064 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL153406 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL153002 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL155103 | — | Ki | = | 7400.0 | nM | 5.13 |