Compound Detail
CHEMBL155485
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Basic Information
| ChEMBL ID | CHEMBL155485 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SOXAQSNKOQZEFX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
295.3
MW (Da)
1.76
ALogP
5
HBA
3
HBD
91.5
PSA (Ų)
0.50
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA CHEMBL2093871 | IC50 | 7.75 | 7.75 | 18.0 | 1 |
| Glutamate NMDA receptor CHEMBL1907608 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, AMPA | IC50 | = | 18.0 | nM | 7.75 | The compound was tested for its affinity for Ionotropic glutamate receptor AMPA ... | 10741560 |
| Glutamate NMDA receptor | IC50 | = | 100000.0 | nM | 4.0 | In vitro affinity for N-methyl-D-aspartate glutamate receptor 1 using [3H]5,7-di... | 10741560 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10741560 | 10.1016/s0960-894x(00)00054-8 | Glutamate receptor ionotropic, AMPA | 1 |
| 10741560 | 10.1016/s0960-894x(00)00054-8 | Glutamate NMDA receptor | 1 |
Data from ChEMBL 36 via Core Engine