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Compound Detail

CHEMBL156437

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NC(=O)Cc1ccc(Cl)cc1

Basic Information

ChEMBL ID CHEMBL156437
Phase Preclinical
Structure Type MOL
InChI Key BFYGROHYLCZLGS-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

169.6
MW (Da)
1.37
ALogP
1
HBA
1
HBD
43.1
PSA (Ų)
0.71
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C8H8ClNO
MW 169.61
Aromatic Rings 1
Heavy Atoms 11
NP-Likeness -1.14

Activity Summary

Ki 1 meas. best 4.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alcohol dehydrogenase
CHEMBL2111372
Ki 4.7 4.7 19952.6 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Alcohol dehydrogenase Ki = 19952.62 nM 4.7 Inhibitory activity against horse liver alcohol dehydrogenase (ADH) 2939242

Literature References

PubMed DOI Target Context # Activities
2939242 10.1021/jm00155a005 Alcohol dehydrogenase 1
2939242 10.1021/jm00155a005 No relevant target 1

Data from ChEMBL 36 via Core Engine