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Assay Detail

CHEMBL645176

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Binding
Inhibitory activity against horse liver alcohol dehydrogenase (ADH)
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Equus caballus
Confidence 5 — Multiple protein complex / RNA
Curated By Intermediate

Target

Alcohol dehydrogenase (CHEMBL2111372)
Type PROTEIN FAMILY
Organism Equus caballus

Publication

A quantitative structure-activity relationship and molecular graphics analysis of hydrophobic effects in the interactions of inhibitors with alcohol dehydrogenase.
Hansch C, Klein T, McClarin J, Langridge R, Cornell NW.
J Med Chem (1986) 29 : 615 -620
PubMed 2939242 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 42 5.95 8.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL160460 1 8.88
CHEMBL156094 1 8.60
CHEMBL345910 1 7.82
CHEMBL351768 1 7.65
CHEMBL449955 1 7.58
CHEMBL156155 1 7.52
CHEMBL158183 1 7.40
CHEMBL1308 FOMEPIZOLE 4.0 1 6.85
CHEMBL351794 1 6.00
CHEMBL348324 1 5.92
CHEMBL346707 1 5.75
CHEMBL15967 PYRAZOLE 1 5.73
CHEMBL155736 1 5.70
CHEMBL155857 1 5.70
CHEMBL46293 1 5.52
CHEMBL157956 1 5.22
CHEMBL345636 1 5.15
CHEMBL156355 1 5.10
CHEMBL351777 1 4.70
CHEMBL156437 1 4.70
CHEMBL157245 1 4.60
CHEMBL160368 1 4.19
CHEMBL157604 1 4.15
CHEMBL157024 1 4.10
CHEMBL157192 1 4.10
CHEMBL276727 IODOACETAMIDE 1 -
CHEMBL53752 1 -
CHEMBL60628 1 -
CHEMBL347645 1 -
CHEMBL352219 ISOBUTYRAMIDE 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL160460 Ki = 1.318 nM 8.88
CHEMBL156094 Ki = 2.512 nM 8.60
CHEMBL345910 Ki = 15.14 nM 7.82
CHEMBL351768 Ki = 22.39 nM 7.65
CHEMBL449955 Ki = 26.3 nM 7.58
CHEMBL156155 Ki = 30.2 nM 7.52
CHEMBL158183 Ki = 39.81 nM 7.40
CHEMBL1308 FOMEPIZOLE Ki = 141.25 nM 6.85
CHEMBL351794 Ki = 1000.0 nM 6.00
CHEMBL348324 Ki = 1202.26 nM 5.92
CHEMBL346707 Ki = 1778.28 nM 5.75
CHEMBL15967 PYRAZOLE Ki = 1862.09 nM 5.73
CHEMBL155736 Ki = 1995.26 nM 5.70
CHEMBL155857 Ki = 1995.26 nM 5.70
CHEMBL46293 Ki = 3019.95 nM 5.52
CHEMBL157956 Ki = 6025.6 nM 5.22
CHEMBL345636 Ki = 7079.46 nM 5.15
CHEMBL156355 Ki = 7943.28 nM 5.10
CHEMBL351777 Ki = 19952.62 nM 4.70
CHEMBL156437 Ki = 19952.62 nM 4.70
CHEMBL157245 Ki = 25118.86 nM 4.60
CHEMBL160368 Ki = 64565.42 nM 4.19
CHEMBL157604 Ki = 70794.58 nM 4.15
CHEMBL157024 Ki = 79432.82 nM 4.10
CHEMBL157192 Ki = 79432.82 nM 4.10
CHEMBL160811 MONOFLUOROACETAMIDE Ki = 38904514.5 nM -
CHEMBL156196 Ki = 3235936.57 nM -
CHEMBL117012 TRIFLUOROACETAMIDE Ki = 46773514.13 nM -
CHEMBL346368 Ki = 7585775.75 nM -
CHEMBL156653 Ki = 6456542.29 nM -
CHEMBL158237 Ki = 954992.59 nM -
CHEMBL58562 Ki = 1288249.55 nM -
CHEMBL156852 Ki = 75857757.5 nM -
CHEMBL348107 ACRYLAMIDE Ki = 7762471.17 nM -
CHEMBL331157 Ki = 8511380.38 nM -
CHEMBL345235 PIVALAMIDE Ki = 3467368.5 nM -
CHEMBL349570 Ki = 389045.14 nM -
CHEMBL352219 ISOBUTYRAMIDE Ki = 169824.37 nM -
CHEMBL347645 Ki = 141253.75 nM -
CHEMBL60628 Ki = 5754399.37 nM -
CHEMBL53752 Ki = 707945.78 nM -
CHEMBL276727 IODOACETAMIDE Ki = 1905460.72 nM -