Compound Detail
CHEMBL160847
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Basic Information
| ChEMBL ID | CHEMBL160847 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ULFBYLWJDCVFRO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
453.5
MW (Da)
4.83
ALogP
5
HBA
1
HBD
75.1
PSA (Ų)
0.48
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | Ki | 7.96 | 7.96 | 11.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | Ki | = | 11.0 | nM | 7.96 | Inhibitory activity against human Phosphodiesterase 5 | 14736245 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14736245 | 10.1021/jm020521s | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine