Assay Detail
Binding
CHEMBL762498
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Inhibitory activity against human Phosphodiesterase 5
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of N-acyl pyrroloquinolone PDE-5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 8.39 | 9.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL158374 | — | — | 1 | 9.66 |
| CHEMBL351813 | — | — | 1 | 9.64 |
| CHEMBL158817 | — | — | 1 | 9.54 |
| CHEMBL263000 | — | — | 1 | 9.46 |
| CHEMBL157819 | — | — | 1 | 9.24 |
| CHEMBL161408 | — | — | 1 | 8.97 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.72 |
| CHEMBL344366 | — | — | 1 | 8.60 |
| CHEMBL158829 | — | — | 1 | 8.46 |
| CHEMBL345179 | — | — | 1 | 8.34 |
| CHEMBL160847 | — | — | 1 | 7.96 |
| CHEMBL157701 | — | — | 1 | 7.90 |
| CHEMBL422006 | — | — | 1 | 7.63 |
| CHEMBL158633 | — | — | 1 | 6.95 |
| CHEMBL160556 | — | — | 1 | 6.93 |
| CHEMBL349299 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL158374 | — | Ki | = | 0.22 | nM | 9.66 |
| CHEMBL351813 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL158817 | — | Ki | = | 0.29 | nM | 9.54 |
| CHEMBL263000 | — | Ki | = | 0.35 | nM | 9.46 |
| CHEMBL157819 | — | Ki | = | 0.58 | nM | 9.24 |
| CHEMBL161408 | — | Ki | = | 1.06 | nM | 8.97 |
| CHEMBL192 | SILDENAFIL | Ki | = | 1.91 | nM | 8.72 |
| CHEMBL344366 | — | Ki | = | 2.49 | nM | 8.60 |
| CHEMBL158829 | — | Ki | = | 3.48 | nM | 8.46 |
| CHEMBL345179 | — | Ki | = | 4.53 | nM | 8.34 |
| CHEMBL160847 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL157701 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL422006 | — | Ki | = | 23.3 | nM | 7.63 |
| CHEMBL158633 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL160556 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL349299 | — | Ki | = | 601.0 | nM | 6.22 |