Compound Detail
CHEMBL422006
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Basic Information
| ChEMBL ID | CHEMBL422006 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CYBPJTIFGMMOIV-RMKNXTFCSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
422.5
MW (Da)
5.29
ALogP
5
HBA
1
HBD
54.8
PSA (Ų)
0.48
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 7.63
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase CHEMBL1827 | Ki | 7.63 | 7.63 | 23.3 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| cGMP-specific 3',5'-cyclic phosphodiesterase | Ki | = | 23.3 | nM | 7.63 | Inhibitory activity against human Phosphodiesterase 5 | 14736245 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 14736245 | 10.1021/jm020521s | cGMP-specific 3',5'-cyclic phosphodiesterase | 1 |
Data from ChEMBL 36 via Core Engine