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Compound Detail

CHEMBL161084

MIRFENTANIL
🧪 Phase II
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🧪 Phase II
O=C(c1ccco1)N(c1cnccn1)C1CCN(CCc2ccccc2)CC1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL161084
Name MIRFENTANIL
Phase Phase II
Structure Type MOL
InChI Key BJZZDOLVVLWFHN-UHFFFAOYSA-N

Known Names

A 3508 Mirfentanil Mirfentanilo Mirfentanyl MS 32 (RECEPTOR BINDER) OHM 10579
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
6
Known Names

Molecular Properties

376.5
MW (Da)
3.42
ALogP
5
HBA
0
HBD
62.5
PSA (Ų)
0.66
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product
USAN Stem -fentanil
USAN Year 1990

Extended Properties

Molecular Formula C22H24N4O2
MW 376.46
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness -1.54

Activity Summary

Ki 1 meas. best 8.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Mu-type opioid receptor
CHEMBL270
 Ki 8.12 8.12 7.5 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Mu-type opioid receptor Ki = 7.5 nM 8.12 Displacement [3H]-naloxone from the Opioid receptor mu 1 isolated from rat brain... 2563773

Literature References

PubMed DOI Target Context # Activities
2563773 10.1021/jm00123a028 Mus musculus 4
2563773 10.1021/jm00123a028 Oryctolagus cuniculus 4
2563773 10.1021/jm00123a028 Rattus norvegicus 2
2563773 10.1021/jm00123a028 Mu-type opioid receptor 1

Data from ChEMBL 36 via Core Engine