Compound Detail
CHEMBL16285
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CCC(OCCc1c2c3c(c(OCc4ccc(-c5ccccc5)cn4)ccc3n1Cc1ccc(Cl)cc1)CC(C)S2)C(=O)NS(C)(=O)=O
Basic Information
| ChEMBL ID | CHEMBL16285 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GIGUYVMODSMFQE-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
3
PK Parameters
4
Publications
0
Known Names
Molecular Properties
704.3
MW (Da)
7.43
ALogP
8
HBA
1
HBD
99.5
PSA (Ų)
0.14
QED
2
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Homo sapiens CHEMBL372 | IC50 | 8.19 | 8.19 | 6.5 | 1 |
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL215 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 4000.0 | nM | Rattus norvegicus |
| F | 72.0 | % | Rattus norvegicus |
| Tmax | 4.0 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Homo sapiens | IC50 | = | 6.5 | nM | 8.19 | Effect on production of LTB4 in human polymorphonuclear leukocytes | 8164257 |
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 20.0 | nM | 7.7 | In vitro inhibition of human 5-Lipoxygenase. | 8164257 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8164257 | 10.1021/jm00034a013 | Rattus norvegicus | 2 |
| 8164257 | 10.1021/jm00034a013 | Polyunsaturated fatty acid 5-lipoxygenase | 1 |
| 8164257 | 10.1021/jm00034a013 | Homo sapiens | 1 |
| 8164257 | 10.1021/jm00034a013 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine