Assay Detail
Functional
CHEMBL761040
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Effect on production of LTB4 in human polymorphonuclear leukocytes
24
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.78 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275634 | — | — | 5 | 8.46 |
| CHEMBL277746 | — | — | 1 | 8.35 |
| CHEMBL13931 | — | — | 1 | 8.30 |
| CHEMBL16567 | — | — | 1 | 8.22 |
| CHEMBL16285 | — | — | 1 | 8.19 |
| CHEMBL278027 | — | — | 1 | 8.15 |
| CHEMBL278632 | — | — | 1 | 8.15 |
| CHEMBL279871 | — | — | 1 | 8.00 |
| CHEMBL16244 | — | — | 1 | 7.96 |
| CHEMBL16284 | — | — | 1 | 7.92 |
| CHEMBL279194 | — | — | 1 | 7.82 |
| CHEMBL16304 | — | — | 1 | 7.77 |
| CHEMBL16389 | — | — | 1 | 7.77 |
| CHEMBL276593 | — | — | 1 | 7.70 |
| CHEMBL16283 | — | — | 1 | 7.51 |
| CHEMBL16366 | — | — | 1 | 7.30 |
| CHEMBL278478 | — | — | 1 | 7.19 |
| CHEMBL16591 | — | — | 1 | 6.95 |
| CHEMBL16590 | — | — | 1 | 6.70 |
| CHEMBL16574 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275634 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL275634 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL277746 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL13931 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL16567 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL16285 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL275634 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL278632 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL278027 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL275634 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL279871 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL16244 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL16284 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL279194 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL275634 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL16304 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL16389 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL276593 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL16283 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL16366 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL278478 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL16591 | — | IC50 | = | 113.0 | nM | 6.95 |
| CHEMBL16590 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL16574 | — | IC50 | = | 1100.0 | nM | 5.96 |