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Compound Detail

CHEMBL1630211

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COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@@]5(C(=O)O)C[C@@H]5/C=C\CCCCC[C@@H](NC(=O)OC(C)(C)C)C(=O)N4C3)cc(-c3ccccn3)nc2c1

Basic Information

ChEMBL ID CHEMBL1630211
Phase Preclinical
Structure Type MOL
InChI Key HEJJPXYSCDXELC-AEQRRLRWSA-N
1
Targets
7
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

699.8
MW (Da)
5.03
ALogP
9
HBA
3
HBD
169.3
PSA (Ų)
0.30
QED
2
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C38H45N5O8
MW 699.81
Aromatic Rings 3
Heavy Atoms 51
NP-Likeness 0.08

Activity Summary

EC50 7 meas. best 8.18

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Hepatitis C virus
CHEMBL379
EC50 8.18 7.4529 6.6 7

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18694956 10.1128/aac.00533-08 Hepatitis C virus 13

Data from ChEMBL 36 via Core Engine