Assay Detail
Functional
CHEMBL1635860
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Antiviral activity against Hepatitis C virus isolate Con1 transfected with NS5B polymerase of HCV genotype 4a infected in human Huh7.5 cells assessed as decrease in viral RNA replication after 3 days by hRLuc reporter gene assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis C virus polymerase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 6.02 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1630211 | — | — | 1 | 7.28 |
| CHEMBL1092581 | NESBUVIR | 2.0 | 1 | 7.16 |
| CHEMBL368589 | — | — | 1 | 5.82 |
| CHEMBL1630212 | — | — | 1 | 5.66 |
| CHEMBL438605 | — | — | 1 | 5.60 |
| CHEMBL403145 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1630211 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1092581 | NESBUVIR | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL368589 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1630212 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL438605 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL403145 | — | EC50 | = | 25000.0 | nM | 4.60 |