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Compound Detail

CHEMBL1630212

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CC(C)C#Cc1cc(N(C(=O)[C@H]2CC[C@H](C)CC2)C(C)C)c(C(=O)O)s1

Basic Information

ChEMBL ID CHEMBL1630212
Phase Preclinical
Structure Type MOL
InChI Key WBMKPKBOOXKYSQ-WKILWMFISA-N
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

375.5
MW (Da)
5.02
ALogP
3
HBA
1
HBD
57.6
PSA (Ų)
0.75
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H29NO3S
MW 375.53
Aromatic Rings 1
Heavy Atoms 26
NP-Likeness -0.35

Activity Summary

EC50 5 meas. best 7.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Hepatitis C virus
CHEMBL379
EC50 7.7 6.574 20.0 5

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18694956 10.1128/aac.00533-08 Hepatitis C virus 16

Data from ChEMBL 36 via Core Engine