Compound Detail
CHEMBL1630380
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Basic Information
| ChEMBL ID | CHEMBL1630380 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VBDRHIJGEFBGCV-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
528.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 8.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor delta CHEMBL3979 | EC50 | 8.35 | 8.35 | 4.5 | 1 |
| Peroxisome proliferator-activated receptor alpha CHEMBL239 | EC50 | 7.82 | 7.82 | 15.2 | 1 |
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | EC50 | 7.0 | 7.0 | 100.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor delta | EC50 | = | 4.5 | nM | 8.35 | Agonist activity at human PPAR-delta expressed in african green monkey CV-1 cell... | 21074432 |
| Peroxisome proliferator-activated receptor alpha | EC50 | = | 15.2 | nM | 7.82 | Agonist activity at human PPAR-alpha expressed in african green monkey CV-1 cell... | 21074432 |
| Peroxisome proliferator-activated receptor gamma | EC50 | = | 100.2 | nM | 7.0 | Agonist activity at human PPAR-gamma expressed in african green monkey CV-1 cell... | 21074432 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21074432 | 10.1016/j.bmcl.2010.10.103 | Peroxisome proliferator-activated receptor alpha | 1 |
| 21074432 | 10.1016/j.bmcl.2010.10.103 | Peroxisome proliferator-activated receptor delta | 1 |
| 21074432 | 10.1016/j.bmcl.2010.10.103 | Peroxisome proliferator-activated receptor gamma | 1 |
Data from ChEMBL 36 via Core Engine