Assay Detail
Functional
CHEMBL1640279
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPAR-delta expressed in african green monkey CV-1 cells after 24 hrs by luciferase reporter gene assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor delta (CHEMBL3979) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Selective peroxisome proliferator-activated receptor δ isosteric selenium agonists as potent anti-atherogenic agents in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 8.44 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1169827 | — | — | 1 | 9.05 |
| CHEMBL1630383 | — | — | 1 | 9.00 |
| CHEMBL1630384 | — | — | 1 | 8.74 |
| CHEMBL1630380 | — | — | 1 | 8.35 |
| CHEMBL1630381 | — | — | 1 | 8.21 |
| CHEMBL1630385 | — | — | 1 | 8.15 |
| CHEMBL1630386 | — | — | 1 | 8.07 |
| CHEMBL1630382 | — | — | 1 | 7.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1169827 | — | EC50 | = | 0.9 | nM | 9.05 |
| CHEMBL1630383 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1630384 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL1630380 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1630381 | — | EC50 | = | 6.2 | nM | 8.21 |
| CHEMBL1630385 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1630386 | — | EC50 | = | 8.5 | nM | 8.07 |
| CHEMBL1630382 | — | EC50 | = | 11.0 | nM | 7.96 |