Compound Detail
CHEMBL1632154
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Basic Information
| ChEMBL ID | CHEMBL1632154 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KLCKNYYQLUGKAN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
344.4
MW (Da)
2.90
ALogP
4
HBA
2
HBD
82.6
PSA (Ų)
0.75
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 9.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 CHEMBL1875 | Ki | 9.09 | 9.09 | 0.8 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Ki | = | 0.8128 | nM | 9.09 | Antagonistic activity at human 5HT4 receptor expressed in HEK293 cells | 21075638 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21075638 | 10.1016/j.bmc.2010.10.011 | 5-hydroxytryptamine receptor 4 | 2 |
Data from ChEMBL 36 via Core Engine