Compound Detail
CHEMBL16467
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL16467 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KSPQIBYPCZOIBJ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
349.4
MW (Da)
0.97
ALogP
4
HBA
3
HBD
98.7
PSA (Ų)
0.31
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Neprilysin CHEMBL3369 | IC50 | 6.1 | 6.1 | 800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Neprilysin | IC50 | = | 800.0 | nM | 6.1 | In vitro inhibition of enkephalinase purified from rat kidney. | 3897541 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3897541 | 10.1021/jm00147a007 | Neprilysin | 1 |
Data from ChEMBL 36 via Core Engine