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Compound Detail

CHEMBL1650592

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Br.CN(C)C(CCCCC[N+](C)(C)CCCN1C(=O)c2cccc3cccc(c23)C1=O)CCCN1C(=O)c2cccc3cccc(c23)C1=O.[Br-]

Basic Information

ChEMBL ID CHEMBL1650592
Phase Preclinical
Structure Type MOL
InChI Key HQPMUSQXQSLJAK-UHFFFAOYSA-M
Parent Compound CHEMBL1739684
Active Moiety CHEMBL1739684
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

647.8
MW (Da)
6.62
ALogP
5
HBA
0
HBD
78.0
PSA (Ų)
0.08
QED
2
Ro5 Violations
15
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C40H48Br2N4O4
MW 808.66
Aromatic Rings 4
Heavy Atoms 48
NP-Likeness -0.19

Activity Summary

IC50 6 meas. best 5.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Mycolicibacterium smegmatis
CHEMBL613088
IC50 5.22 5.08 6000.0 6

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
19786608 10.1128/aac.00803-09 Mycolicibacterium smegmatis 12

Data from ChEMBL 36 via Core Engine