Compound Detail
CHEMBL1672682
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Basic Information
| ChEMBL ID | CHEMBL1672682 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UGYSMGXRWBTMRZ-KTKRTIGZSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
381.6
MW (Da)
6.69
ALogP
2
HBA
2
HBD
49.3
PSA (Ų)
0.17
QED
1
Ro5 Violations
21
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.13
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 2 CHEMBL2863 | IC50 | 6.13 | 6.13 | 740.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 2 | IC50 | = | 740.0 | nM | 6.13 | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed ... | 30176215 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30176215 | 10.1021/acs.jmedchem.8b00734 | Transient receptor potential cation channel subfamily V member 2 | 3 |
| 21257314 | 10.1016/j.bmc.2010.12.046 | HaCaT | 2 |
| 31618024 | 10.1021/acs.jmedchem.9b00994 | RBL-2H3 | 1 |
Data from ChEMBL 36 via Core Engine