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Target Snapshot

CHEMBL2863 Target Snapshot

Transient receptor potential cation channel subfamily V member 2 · SINGLE PROTEIN · Rattus norvegicus

69Compounds
21Assays
2Approved Drugs
129.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9WUD2. Use UniProt Q9WUD2 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9WUD2 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Transient receptor potential cation channel subfamily V member 2 as ChEMBL target CHEMBL2863, mapped to UniProt Q9WUD2. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Transient receptor potential cation channel subfamily V member 2
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL2863
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9WUD2
Transient receptor potential cation channel subfamily V member 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Transient receptor potential cation channel subfamily V member 2 is the right protein anchor across sources, using UniProt Q9WUD2 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTransient receptor potential cation channel subfamily V member 2
UniProt AccessionQ9WUD2
Component TypeProtein
Sequence Length761 aa

Transient receptor potential cation channel subfamily V member 2

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Transient receptor potential cation channel subfamily V member 2, mapped to UniProt Q9WUD2. Sequence length is 761 aa.

Mapped IDQ9WUD2
Review nameTransient receptor potential cation channel subfamily V member 2
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase III
3
Phase II
Assay Mix

Activity Type Distribution

IC50117.0
EC5012.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4249976 6.92 IC50 120.0 Preclinical
CHEMBL76903 6.8 IC50 160.0 Clinical
CHEMBL4249973 6.55 IC50 280.0 Preclinical
CHEMBL1672687 6.31 IC50 490.0 Preclinical
CHEMBL149859 6.19 IC50 650.0 Preclinical
CHEMBL1232565 6.17 IC50 670.0 Preclinical
CHEMBL1672682 6.13 IC50 740.0 Preclinical
CHEMBL4243028 6.09 IC50 820.0 Preclinical
CHEMBL15848 6.02 IC50 960.0 Preclinical
CHEMBL4243663 6.01 IC50 980.0 Preclinical
Distribution

pChEMBL Value Distribution

14
5.0
38
5.5
7
6.0
3
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

21
Total Assays
45
Tested Compounds
2
Assay Types
Binding — 17 assays, 45 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 17 45 5.6
Functional — 4 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 2 5.7
assay format 1 1 4.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine