Compound Detail
CHEMBL4243663
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CCCCCCCC/C=C\CCCCCCCC[Se]C[C@H](N)C(=O)NCc1ccc(O)c(OC)c1.O=C(O)C(F)(F)F
Basic Information
| ChEMBL ID | CHEMBL4243663 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AXNMSKUYWUWMQF-ZDAHPACKSA-N |
| Parent Compound | CHEMBL4300135 |
| Active Moiety | CHEMBL4300135 |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
553.7
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 2 CHEMBL2863 | IC50 | 6.01 | 5.89 | 980.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 2 | IC50 | = | 980.0 | nM | 6.01 | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed ... | 30176215 |
| Transient receptor potential cation channel subfamily V member 2 | IC50 | = | 1700.0 | nM | 5.77 | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed ... | 30176215 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30176215 | 10.1021/acs.jmedchem.8b00734 | Transient receptor potential cation channel subfamily V member 2 | 4 |
Data from ChEMBL 36 via Core Engine