Compound Detail
CHEMBL167731
PIXANTRONE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL167731 |
| Name | PIXANTRONE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | PEZPMAYDXJQYRV-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
5
Known Names
8
Indications
1
Mechanisms
Molecular Properties
325.4
MW (Da)
0.60
ALogP
7
HBA
4
HBD
123.1
PSA (Ų)
0.52
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2012 |
| Availability | Unknown |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| DNA cross-linking agent | CROSS-LINKING AGENT | DNA | ✓ | ✓ |
Indications
Neoplasms Lymphoma Lymphoma, Follicular Lymphoma, Follicular Lymphoma, Large B-Cell, Diffuse Lymphoma, Non-Hodgkin Leukemia, Lymphocytic, Chronic, B-Cell Leukemia, Myeloid, Acute
ATC Classification
L01DB11
pixantrone
Level 1: ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
Level 2: ANTINEOPLASTIC AGENTS
Activity Summary
IC50 4 meas. best 7.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 7.38 | 7.3525 | 42.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 42.06 | nM | 7.38 | PubChem BioAssay. Decreased HeLa cell count-IC50. (Class of assay: confirmator... | - |
| Unchecked | IC50 | = | 42.0 | nM | 7.38 | PubChem BioAssay. Increased HeLa cells with 2N DNA content-IC50. (Class of ass... | - |
| Unchecked | IC50 | = | 46.5 | nM | 7.33 | PubChem BioAssay. VEGF stimulated ADSC/ECFC co-culture CD31-stained tube area de... | - |
| Unchecked | IC50 | = | 48.29 | nM | 7.32 | PubChem BioAssay. Increased HeLa cells with 4N DNA content-IC50. (Class of ass... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18232651 | 10.1021/jm7013937 | HT-29 | 15 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 3 |
| 8145234 | 10.1021/jm00032a018 | LoVo | 2 |
| 8145234 | 10.1021/jm00032a018 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine