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Compound Detail

CHEMBL1683595

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C=C1C[C@@H]2CC[C@@]34C[C@H]5O[C@H]6[C@@H](O3)[C@H]3O[C@H](CC[C@@H]3O[C@H]6[C@H]5O4)CC(=O)C[C@@H]3[C@@H](OC)[C@@H](C[C@@H](CN4CCN(C(=O)OCC)CC4)OC)O[C@H]3C[C@H]3O[C@@H](CC[C@@H]1O2)C[C@@H](C)C3=C

Basic Information

ChEMBL ID CHEMBL1683595
Phase Preclinical
Structure Type MOL
InChI Key SPDOSSRFVFWWGB-WLNQARJTSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

885.1
MW (Da)
4.91
ALogP
14
HBA
0
HBD
142.2
PSA (Ų)
0.32
QED
2
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C48H72N2O13
MW 885.10
Aromatic Rings 0
Heavy Atoms 63
NP-Likeness 1.19

Activity Summary

IC50 2 meas. best 10.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
IC50 10.1 9.31 0.1 2

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
NON-PROTEIN TARGET IC50 = 0.08 nM 10.1 Cytotoxicity against human MES-SA cells 21324692
NON-PROTEIN TARGET IC50 = 3.05 nM 8.52 Cytotoxicity against human MES-SA/Dx5-Rx1 cells 21324692

Literature References

PubMed DOI Target Context # Activities
21324692 10.1016/j.bmcl.2011.01.097 NON-PROTEIN TARGET 2
21324692 10.1016/j.bmcl.2011.01.097 MES-SA 1
21324692 10.1016/j.bmcl.2011.01.097 DLD-1 1
21324692 10.1016/j.bmcl.2011.01.097 HCT-15 1

Data from ChEMBL 36 via Core Engine