Compound Detail
CHEMBL1685068
DIMETHYLCRYPTOSTROBIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL1685068 |
| Name | DIMETHYLCRYPTOSTROBIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RIEGMKITKZWJHR-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
298.3
MW (Da)
3.72
ALogP
4
HBA
0
HBD
44.8
PSA (Ų)
0.87
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 5.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Broad substrate specificity ATP-binding cassette transporter ABCG2 CHEMBL5393 | IC50 | 5.03 | 4.9 | 9300.0 | 2 |
| ATP-dependent translocase ABCB1 CHEMBL4302 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.72 | 4.72 | 19000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | IC50 | = | 9300.0 | nM | 5.03 | Inhibition of BCRP expressed in MDCK cells using Hoechst 33342 staining | 21354800 |
| ATP-dependent translocase ABCB1 | IC50 | = | 15000.0 | nM | 4.82 | Inhibition of MDR1 expressed in MDCK cells using rhodamine 123 staining by flow ... | 21354800 |
| Broad substrate specificity ATP-binding cassette transporter ABCG2 | IC50 | = | 17000.0 | nM | 4.77 | Inhibition of BCRP expressed in MCF-7 MX cells using Hoechst 33342 staining | 21354800 |
| Unchecked | IC50 | = | 19000.0 | nM | 4.72 | Inhibition of P-gp expressed in A2780adr cells by calcein AM accumulation assay | 21354800 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21354800 | 10.1016/j.bmc.2010.12.043 | Broad substrate specificity ATP-binding cassette transporter ABCG2 | 2 |
| 21354800 | 10.1016/j.bmc.2010.12.043 | Unchecked | 2 |
| 21354800 | 10.1016/j.bmc.2010.12.043 | MCF7 | 1 |
| 21354800 | 10.1016/j.bmc.2010.12.043 | ATP-dependent translocase ABCB1 | 1 |
| 21354800 | 10.1016/j.bmc.2010.12.043 | A2780 | 1 |
Data from ChEMBL 36 via Core Engine