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Compound Detail

CHEMBL169290

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c1cncc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2cccnc2)c1

Basic Information

ChEMBL ID CHEMBL169290
Phase Preclinical
Structure Type MOL
InChI Key NGSWBKMVOVXLSX-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

524.8
MW (Da)
6.00
ALogP
6
HBA
4
HBD
73.9
PSA (Ų)
0.11
QED
2
Ro5 Violations
27
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H56N6
MW 524.84
Aromatic Rings 2
Heavy Atoms 38
NP-Likeness -0.39

Activity Summary

Kd 2 meas. best 6.54

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Kd 6.54 6.54 288.4 1
Muscarinic acetylcholine receptor M3
CHEMBL5498
Kd 5.31 5.31 4897.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2909747 10.1021/jm00121a017 Muscarinic acetylcholine receptor M2 1
2909747 10.1021/jm00121a017 Muscarinic acetylcholine receptor M3 1
2909747 10.1021/jm00121a017 Muscarinic acetylcholine receptors; M2 & M3 1

Data from ChEMBL 36 via Core Engine