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Compound Detail

CHEMBL170793

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Cc1ccc(CNCCCCCCNCCCCCCCCNCCCCCCNCc2ccc(C)o2)o1

Basic Information

ChEMBL ID CHEMBL170793
Phase Preclinical
Structure Type MOL
InChI Key GECJOPJJDDNQIZ-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

530.8
MW (Da)
7.01
ALogP
6
HBA
4
HBD
74.4
PSA (Ų)
0.09
QED
2
Ro5 Violations
27
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H58N4O2
MW 530.84
Aromatic Rings 2
Heavy Atoms 38
NP-Likeness -0.35

Activity Summary

Kd 2 meas. best 8.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL211
Kd 8.05 8.05 8.9 1
Muscarinic acetylcholine receptor M3
CHEMBL5498
Kd 6.15 6.15 708.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2909747 10.1021/jm00121a017 Muscarinic acetylcholine receptor M2 1
2909747 10.1021/jm00121a017 Muscarinic acetylcholine receptor M3 1
2909747 10.1021/jm00121a017 Muscarinic acetylcholine receptors; M2 & M3 1

Data from ChEMBL 36 via Core Engine