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Compound Detail

CHEMBL1713547

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O=C(O)/C=C/C(=O)Nc1ccc(Oc2ccccc2)cc1

Basic Information

ChEMBL ID CHEMBL1713547
Phase Preclinical
Structure Type MOL
InChI Key YSGGHSDBNZOIHX-ZHACJKMWSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

283.3
MW (Da)
3.06
ALogP
3
HBA
2
HBD
75.6
PSA (Ų)
0.83
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C16H13NO4
MW 283.28
Aromatic Rings 2
Heavy Atoms 21
NP-Likeness -0.62

Activity Summary

Kd 1 meas. best 4.53

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Kd 4.53 4.53 29300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked Kd = 29300.0 nM 4.53 Binding affinity to Pseudomonas aeruginosa apo Heme oxygenase expressed in Esche... 23379514

Literature References

PubMed DOI Target Context # Activities
23379514 10.1021/jm301819k Pseudomonas aeruginosa 3
23379514 10.1021/jm301819k Unchecked 1

Data from ChEMBL 36 via Core Engine