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Compound Detail

CHEMBL171832

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O=C(O)Cc1ccccc1Cc1ccccc1-c1nc(C(=O)NCCCCC2CCCCC2)co1

Basic Information

ChEMBL ID CHEMBL171832
Phase Preclinical
Structure Type MOL
InChI Key WCTMICCDCORRLH-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

474.6
MW (Da)
6.04
ALogP
4
HBA
2
HBD
92.4
PSA (Ų)
0.33
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H34N2O4
MW 474.60
Aromatic Rings 3
Heavy Atoms 35
NP-Likeness -0.22

Activity Summary

IC50 2 meas. best 4.17

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Homo sapiens
CHEMBL372
IC50 4.17 4.17 67000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Homo sapiens IC50 = 67000.0 nM 4.17 Tested for inhibition of platelet aggregation induced by arachidonic acid (AAIPA... -

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(00)80592-2 Homo sapiens 2

Data from ChEMBL 36 via Core Engine