Compound Detail
CHEMBL1738990
LEVOPROPOXYPHENE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1738990 |
| Name | LEVOPROPOXYPHENE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | XLMALTXPSGQGBX-PGRDOPGGSA-N |
| Therapeutic | ✓ Yes |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
6
Publications
6
Known Names
Molecular Properties
339.5
MW (Da)
4.28
ALogP
3
HBA
0
HBD
29.5
PSA (Ų)
0.67
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1962 |
| Availability | Discontinued |
| Chirality | Single Enantiomer |
Activity Summary
EC50 2 meas. best 4.82
IC50 1 meas. best 5.56
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 5.56 | 5.56 | 2754.2 | 1 |
| Mas-related G-protein coupled receptor member X2 CHEMBL5849 | EC50 | 4.82 | 4.66 | 15135.6 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 2754.23 | nM | 5.56 | Inhibition of human ERG | 21185626 |
| Mas-related G-protein coupled receptor member X2 | EC50 | = | 15135.61 | nM | 4.82 | Agonist activity at MRGPRX2 (unknown origin) expressed in HTLA cells assessed as... | 28288109 |
| Mas-related G-protein coupled receptor member X2 | EC50 | = | 31622.78 | nM | 4.5 | Agonist activity at N-terminal Flag-tagged human MRGPRX2 receptor expressed in t... | 28288109 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28288109 | 10.1038/nchembio.2334 | Mas-related G-protein coupled receptor member X2 | 4 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 21185626 | 10.1016/j.ejmech.2010.11.042 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine