Compound Detail
CHEMBL174382
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Basic Information
| ChEMBL ID | CHEMBL174382 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OJHPETTZSBWESU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
303.4
MW (Da)
4.92
ALogP
2
HBA
0
HBD
30.0
PSA (Ų)
0.63
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 CHEMBL4477 | IC50 | 6.64 | 6.64 | 230.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 1 | IC50 | = | 230.0 | nM | 6.64 | Inhibitory concentration against rat metabotropic glutamate receptor 1 | 15771457 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15771457 | 10.1021/jm049499o | Metabotropic glutamate receptor 1 | 2 |
| 15771457 | 10.1021/jm049499o | Homo sapiens | 1 |
Data from ChEMBL 36 via Core Engine