Compound Detail
CHEMBL1760688
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Basic Information
| ChEMBL ID | CHEMBL1760688 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DQXJSPWIZXASJC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
373.3
MW (Da)
4.84
ALogP
4
HBA
1
HBD
56.7
PSA (Ų)
0.67
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase type 2 CHEMBL3746 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 11-beta-hydroxysteroid dehydrogenase type 2 | IC50 | = | 2300.0 | nM | 5.64 | Inhibition of human 11beta-HSD2 | 21334894 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21334894 | 10.1016/j.bmcl.2011.01.125 | Mus musculus | 2 |
| 21334894 | 10.1016/j.bmcl.2011.01.125 | Nuclear receptor subfamily 1 group I member 2 | 2 |
| 21334894 | 10.1016/j.bmcl.2011.01.125 | 11-beta-hydroxysteroid dehydrogenase 1 | 1 |
| 21334894 | 10.1016/j.bmcl.2011.01.125 | 11-beta-hydroxysteroid dehydrogenase type 2 | 1 |
Data from ChEMBL 36 via Core Engine