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Compound Detail

CHEMBL1760804

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Cn1c(-c2ccc(-c3cccnc3)cc2O)nnc1C1(c2ccc(Cl)cc2)CCC1

Basic Information

ChEMBL ID CHEMBL1760804
Phase Preclinical
Structure Type MOL
InChI Key ZSTHUWVKZPCGCW-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

416.9
MW (Da)
5.37
ALogP
5
HBA
1
HBD
63.8
PSA (Ų)
0.49
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H21ClN4O
MW 416.91
Aromatic Rings 4
Heavy Atoms 30
NP-Likeness -0.57

Activity Summary

IC50 2 meas. best 9.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
11-beta-hydroxysteroid dehydrogenase 1
CHEMBL3910
IC50 9.0 9.0 1.0 1
11-beta-hydroxysteroid dehydrogenase 1
CHEMBL4235
IC50 7.42 7.42 38.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
21334894 10.1016/j.bmcl.2011.01.125 11-beta-hydroxysteroid dehydrogenase type 2 2
21334894 10.1016/j.bmcl.2011.01.125 11-beta-hydroxysteroid dehydrogenase 1 2
21334894 10.1016/j.bmcl.2011.01.125 Mus musculus 2
21334894 10.1016/j.bmcl.2011.01.125 Nuclear receptor subfamily 1 group I member 2 2

Data from ChEMBL 36 via Core Engine