Assay Detail
Binding
CHEMBL1764757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation counting
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
11-beta-hydroxysteroid dehydrogenase 1 (CHEMBL3910) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Substituted phenyl triazoles as selective inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 8.19 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760803 | — | — | 1 | 9.12 |
| CHEMBL1760804 | — | — | 1 | 9.00 |
| CHEMBL1760806 | — | — | 1 | 9.00 |
| CHEMBL1760685 | — | — | 1 | 9.00 |
| CHEMBL1760681 | — | — | 1 | 9.00 |
| CHEMBL1760797 | — | — | 1 | 8.96 |
| CHEMBL522701 | — | — | 1 | 8.89 |
| CHEMBL1760796 | — | — | 1 | 8.82 |
| CHEMBL1760802 | — | — | 1 | 8.80 |
| CHEMBL1760805 | — | — | 1 | 8.77 |
| CHEMBL1760690 | — | — | 1 | 8.72 |
| CHEMBL1760793 | — | — | 1 | 8.70 |
| CHEMBL1760791 | — | — | 1 | 8.66 |
| CHEMBL1760809 | — | — | 1 | 8.64 |
| CHEMBL1760691 | — | — | 1 | 8.59 |
| CHEMBL1760795 | — | — | 1 | 8.55 |
| CHEMBL1760687 | — | — | 1 | 8.55 |
| CHEMBL1760792 | — | — | 1 | 8.54 |
| CHEMBL1760674 | — | — | 1 | 8.52 |
| CHEMBL1760799 | — | — | 1 | 8.47 |
| CHEMBL525361 | — | — | 1 | 8.40 |
| CHEMBL1760798 | — | — | 1 | 8.39 |
| CHEMBL1760800 | — | — | 1 | 8.22 |
| CHEMBL1760676 | — | — | 1 | 8.18 |
| CHEMBL1760673 | — | — | 1 | 8.11 |
| CHEMBL1760683 | — | — | 1 | 8.04 |
| CHEMBL1760684 | — | — | 1 | 7.96 |
| CHEMBL1760675 | — | — | 1 | 7.96 |
| CHEMBL257149 | — | — | 1 | 7.85 |
| CHEMBL1760682 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760803 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL1760804 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1760681 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1760806 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1760685 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1760797 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL522701 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL1760796 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL1760802 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL1760805 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL1760690 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1760793 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1760791 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1760809 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1760691 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL1760795 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1760687 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL1760792 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL1760674 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1760799 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL525361 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1760798 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL1760800 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1760676 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL1760673 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL1760683 | — | IC50 | = | 9.1 | nM | 8.04 |
| CHEMBL1760684 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1760675 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL257149 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1760682 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1760680 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1760672 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL523177 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL1760677 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1760807 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1760671 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL256778 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL1760678 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1760808 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1760679 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1760801 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL1760794 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL1760689 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL1760688 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL1760686 | — | IC50 | < | 1.0 | nM | - |