Compound Detail
CHEMBL1762162
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CC1(C)C(=O)N(c2ccc(SC(F)(F)F)cc2)C(=O)N1Cc1ccnc(NS(C)(=O)=O)c1
Basic Information
| ChEMBL ID | CHEMBL1762162 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HABDHZPUSVXZKC-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
488.5
MW (Da)
3.81
ALogP
6
HBA
1
HBD
99.7
PSA (Ų)
0.49
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.33
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor CHEMBL1957 | IC50 | 5.33 | 5.33 | 4706.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Insulin-like growth factor 1 receptor | IC50 | = | 4706.0 | nM | 5.33 | Inhibition of IGF-induced autophosphosphorylation of GST-tagged human IGF1R expr... | 21441024 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21441024 | 10.1016/j.bmcl.2011.03.003 | Insulin-like growth factor 1 receptor | 1 |
| 21441024 | 10.1016/j.bmcl.2011.03.003 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine