Compound Detail
CHEMBL1762483
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Basic Information
| ChEMBL ID | CHEMBL1762483 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XCSRSXRUZPDJHS-UHFFFAOYSA-N |
6
Targets
6
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
485.0
MW (Da)
5.42
ALogP
6
HBA
0
HBD
51.0
PSA (Ų)
0.45
QED
1
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium/glucose cotransporter 2 CHEMBL4316 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
| Sodium/glucose cotransporter 2 CHEMBL1075302 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Sodium/glucose cotransporter 2 CHEMBL3884 | IC50 | 5.85 | 5.85 | 1400.0 | 1 |
| SGLT1 protein CHEMBL1744523 | IC50 | 5.52 | 5.52 | 3000.0 | 1 |
| Sodium/glucose cotransporter 1 CHEMBL4979 | IC50 | 5.16 | 5.16 | 7000.0 | 1 |
| Sodium/glucose cotransporter 1 CHEMBL5374 | IC50 | 5.05 | 5.05 | 9000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium/glucose cotransporter 2 | IC50 | = | 400.0 | nM | 6.4 | Inhibition of rat SGLT2 expressed in CHO cells assessed as inhibition of [14C]-a... | 21398124 |
| Sodium/glucose cotransporter 2 | IC50 | = | 1200.0 | nM | 5.92 | Inhibition of mouse SGLT2 expressed in CHO cells assessed as inhibition of [14C]... | 21398124 |
| Sodium/glucose cotransporter 2 | IC50 | = | 1400.0 | nM | 5.85 | Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]... | 21398124 |
| SGLT1 protein | IC50 | = | 3000.0 | nM | 5.52 | Inhibition of mouse SGLT1 expressed in CHO cells assessed as inhibition of [14C]... | 21398124 |
| Sodium/glucose cotransporter 1 | IC50 | = | 7000.0 | nM | 5.16 | Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]... | 21398124 |
| Sodium/glucose cotransporter 1 | IC50 | = | 9000.0 | nM | 5.05 | Inhibition of rat SGLT1 expressed in CHO cells assessed as inhibition of [14C]-a... | 21398124 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21398124 | 10.1016/j.bmcl.2011.02.056 | Sodium/glucose cotransporter 2 | 3 |
| 21398124 | 10.1016/j.bmcl.2011.02.056 | Unchecked | 3 |
| 21398124 | 10.1016/j.bmcl.2011.02.056 | Sodium/glucose cotransporter 1 | 2 |
| 21398124 | 10.1016/j.bmcl.2011.02.056 | SGLT1 protein | 1 |
Data from ChEMBL 36 via Core Engine