Compound Detail
CHEMBL1766092
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COc1ccc(-c2cc3c(OCC[C@H]4CCCCN4)c(-c4cc(C)cc(C)c4)cnc3cc2Cl)cn1
Basic Information
| ChEMBL ID | CHEMBL1766092 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DJYFUVCIZAKTJT-HSZRJFAPSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
502.1
MW (Da)
7.15
ALogP
5
HBA
1
HBD
56.3
PSA (Ų)
0.29
QED
2
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.3
Ki 1 meas. best 9.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 2 CHEMBL1804 | Ki | 9.19 | 9.19 | 0.7 | 1 |
| Somatostatin receptor type 2 CHEMBL1804 | IC50 | 7.3 | 7.3 | 50.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 2 | Ki | = | 0.65 | nM | 9.19 | Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells afte... | 21395312 |
| Somatostatin receptor type 2 | IC50 | = | 50.0 | nM | 7.3 | Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of ... | 21395312 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21395312 | 10.1021/jm101501b | Somatostatin receptor type 2 | 2 |
Data from ChEMBL 36 via Core Engine