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Assay Detail

CHEMBL1767825

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells after 3 hrs by scintillation counting
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Somatostatin receptor type 2 (CHEMBL1804)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design, synthesis, and evaluation of novel 3,6-diaryl-4-aminoalkoxyquinolines as selective agonists of somatostatin receptor subtype 2.
Wolkenberg SE, Zhao Z, Thut C, Maxwell JW, McDonald TP, Kinose F, Reilly M, Lindsley CW, Hartman GD.
J Med Chem (2011) 54 : 2351 -2358
PubMed 21395312 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 9.58 10.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1766100 1 10.60
CHEMBL1766103 1 10.60
CHEMBL1766097 1 10.43
CHEMBL1766099 1 10.42
CHEMBL1766109 1 10.21
CHEMBL1766102 1 10.10
CHEMBL1766096 1 10.10
CHEMBL1766098 1 10.00
CHEMBL1766095 1 9.96
CHEMBL1766094 1 9.92
CHEMBL1766104 1 9.89
CHEMBL1766089 1 9.89
CHEMBL1766093 1 9.89
CHEMBL1766105 1 9.89
CHEMBL1766110 1 9.74
CHEMBL1766090 1 9.57
CHEMBL1766091 1 9.22
CHEMBL1766092 1 9.19
CHEMBL1766101 1 8.82
CHEMBL1766107 1 8.82
CHEMBL1766108 1 7.70
CHEMBL1766106 1 5.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1766100 Ki = 0.025 nM 10.60
CHEMBL1766103 Ki = 0.025 nM 10.60
CHEMBL1766097 Ki = 0.037 nM 10.43
CHEMBL1766099 Ki = 0.038 nM 10.42
CHEMBL1766109 Ki = 0.062 nM 10.21
CHEMBL1766102 Ki = 0.08 nM 10.10
CHEMBL1766096 Ki = 0.08 nM 10.10
CHEMBL1766098 Ki = 0.1 nM 10.00
CHEMBL1766095 Ki = 0.11 nM 9.96
CHEMBL1766094 Ki = 0.12 nM 9.92
CHEMBL1766104 Ki = 0.13 nM 9.89
CHEMBL1766089 Ki = 0.13 nM 9.89
CHEMBL1766093 Ki = 0.13 nM 9.89
CHEMBL1766105 Ki = 0.13 nM 9.89
CHEMBL1766110 Ki = 0.18 nM 9.74
CHEMBL1766090 Ki = 0.27 nM 9.57
CHEMBL1766091 Ki = 0.6 nM 9.22
CHEMBL1766092 Ki = 0.65 nM 9.19
CHEMBL1766101 Ki = 1.5 nM 8.82
CHEMBL1766107 Ki = 1.5 nM 8.82
CHEMBL1766108 Ki = 20.0 nM 7.70
CHEMBL1766106 Ki = 1400.0 nM 5.85