Compound Detail
CHEMBL1766110
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Basic Information
| ChEMBL ID | CHEMBL1766110 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MRYYDCIBVWPZNW-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
473.1
MW (Da)
7.47
ALogP
3
HBA
2
HBD
33.3
PSA (Ų)
0.39
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.12
Ki 1 meas. best 9.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 2 CHEMBL1804 | Ki | 9.74 | 9.74 | 0.2 | 1 |
| Somatostatin receptor type 2 CHEMBL1804 | IC50 | 8.12 | 8.12 | 7.6 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 46.0 | mL.min-1.kg-1 | Canis lupus familiaris |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 2 | Ki | = | 0.18 | nM | 9.74 | Displacement of I125-somatostatin-14 from human SST2 expressed in CHO cells afte... | 21395312 |
| Somatostatin receptor type 2 | IC50 | = | 7.6 | nM | 8.12 | Agonist activity at human SST2 expressed in CHO cells assessed as inhibition of ... | 21395312 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21395312 | 10.1021/jm101501b | Unchecked | 4 |
| 21395312 | 10.1021/jm101501b | Somatostatin receptor type 2 | 2 |
| 21395312 | 10.1021/jm101501b | No relevant target | 1 |
| 21395312 | 10.1021/jm101501b | Canis familiaris | 1 |
Data from ChEMBL 36 via Core Engine