Compound Detail
CHEMBL176758
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL176758 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NIQCRSHOBPZURY-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
304.4
MW (Da)
3.89
ALogP
3
HBA
0
HBD
43.4
PSA (Ų)
0.75
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Crithidia fasciculata CHEMBL612650 | IC50 | 6.16 | 6.16 | 700.0 | 1 |
| Leptomonas seymouri CHEMBL612917 | IC50 | 6.16 | 6.16 | 700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Leptomonas seymouri | IC50 | = | 700.0 | nM | 6.16 | Antitrypanosomal activity against Leptomonas seymouri | 18276039 |
| Crithidia fasciculata | IC50 | = | 700.0 | nM | 6.16 | Antitrypanosomal activity against Crithidia fasciculata | 18276039 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 6205152 | 10.1021/jm00374a010 | Rauscher murine leukemia virus | 2 |
| 6205152 | 10.1021/jm00374a010 | Mus musculus | 2 |
| 18276039 | 10.1016/j.ejmech.2007.12.023 | No relevant target | 2 |
| 6205152 | 10.1021/jm00374a010 | Avian myeloblastosis virus | 1 |
| 18276039 | 10.1016/j.ejmech.2007.12.023 | Leptomonas seymouri | 1 |
| 18276039 | 10.1016/j.ejmech.2007.12.023 | Crithidia fasciculata | 1 |
| 21450374 | 10.1016/j.ejmech.2011.03.012 | Trypanosoma cruzi | 1 |
Data from ChEMBL 36 via Core Engine